Computer aided design and NMR characterization of an oligopeptide targeting the Ebola virus VP24 protein-Reference-Cited by-同舟云学术

Computer aided design and NMR characterization of an oligopeptide targeting the Ebola virus VP24 protein

Published:2017 Issue:11 Volume:41 Page:4308-4315
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Dapiaggi Federico¹²³⁴,Pieraccini Stefano¹²³⁴⁵^ORCID,Potenza Donatella¹²³⁴,Vasile Francesca¹²³⁴^ORCID,Macut Helena⁶⁷³⁴,Pellegrino Sara⁶⁷³⁴,Aliverti Alessandro⁸³⁴^ORCID,Sironi Maurizio¹²³⁴⁵

Affiliation:

1. Dipartimento di Chimica

2. Università degli Studi di Milano

3. Milano

4. Italy

5. Istituto di Scienze e Tecnologie Molecolari (INSTM)

6. DISFARM-Dipartimento di Scienze Farmaceutiche

7. Sezione Chimica Generale e Organica “A. Marchesini”

8. Dipartimento di Bioscienze

Abstract

The nona-peptide RS, designed on the basis of computational studies, is able to interact with Ebola VP24 and potentially inhibit its interaction with KPNA.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/NJ/C6NJ04014D

Reference63 articles.

1. Ebola haemorrhagic fever

2. Ebola and Marburg Viruses Replicate in Monocyte‐Derived Dendritic Cells without Inducing the Production of Cytokines and Full Maturation

3. Ebola virus: The role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever

4. Ebola Virus VP24 Binds Karyopherin α1 and Blocks STAT1 Nuclear Accumulation

5. Ebola Virus VP24 Proteins Inhibit the Interaction of NPI-1 Subfamily Karyopherin α Proteins with Activated STAT1

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