Enhanced inhibition of protein disulfide isomerase and anti-thrombotic activity of a rutin derivative: rutin:Zn complex-Reference-Cited by-同舟云学术

Enhanced inhibition of protein disulfide isomerase and anti-thrombotic activity of a rutin derivative: rutin:Zn complex

Published:2023 Issue:17 Volume:13 Page:11464-11471
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Liao Xinyuan¹,Ji Panpan²,Chi Kunxiang¹,Chen Xueying¹,Zhou Yang¹,Chen Shanli¹,Cheng Yuan¹,Flaumenhaft Robert³,Yuan Cai²,Huang Mingdong¹^ORCID

Affiliation:

1. College of Chemistry, Fuzhou University, Fujian 350108, China

2. College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian, 350108, China

3. Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA

Abstract

The chelation of zinc to adjacent keto and phenoxy position was critical for enhancing rutin and flavonoids' inhibition to PDI, which provides a new strategy for the clinical translation of flavonoids.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Natural Science Foundation of Fujian Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA01135F

Reference27 articles.

1. Anti-oxidant capacities of flavonoid compounds isolated from acai pulp (Euterpe oleracea Mart.)

2. Flavonoids as anti-inflammatory agents

3. Antimutagenic Activity of Flavonoids fromChrysanthemum morifolium

4. Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua

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