Chitosan-based multifunctional oxygenating antibiotic hydrogel dressings for managing chronic infection in diabetic wounds

Author:

Abri Shahrzad1,Durr Hannah2,Barton Hazel A.3,Adkins-Travis Kayla4,Shriver Leah P.456,Pukale Dipak D.1,Fulton Judith A.78,Leipzig Nic D.12ORCID

Affiliation:

1. Department of Chemical, Biomolecular, and Corrosion Engineering, The University of Akron, Akron, Ohio 44325, USA

2. Integrated Biosciences Program, Department of Biology, The University of Akron, Akron, Ohio 44325, USA

3. Department of Geological Sciences, The University of Alabama, Tuscaloosa, Alabama 35487, USA

4. Department of Chemistry, Washington University in Saint Louis, Saint Louis, MO 63130, USA

5. Center for Proteomics, Metabolomics, and Isotope Tracing, Washington University in Saint Louis, Saint Louis, MO 63130, USA

6. Department of Medicine, Washington University in Saint Louis, Saint Louis, MO 63130, USA

7. Summa Health System-Translational Research Center Akron, Akron, Ohio 44304, USA

8. Northeast Ohio Medical University-REDIzone, Rootstown, Ohio 44272, USA

Abstract

Fluorinated methacrylamide chitosan hydrogels promote wound healing by reducing bacterial infection, boosting pro-regenerative lipid levels, and increasing wound oxygen levels.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

Royal Society of Chemistry (RSC)

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