The development of a short route to the API ropinirole hydrochloride
Author:
Affiliation:
1. Chemistry
2. University of Southampton
3. Southampton
4. UK
5. GlaxoSmithKline Medicines Research Centre
6. Stevenage
7. Formally at GlaxoSmithKline Innovation and Sustainable Manufacturing COE
8. Worthing
Abstract
A four-step, three-stage synthesis of the API ropinirole hydrochloride has been developed from a commercially available naphthalene derivative.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01739D
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1. Involvement of dopamine (DA)/serotonin (5-HT)/sigma (σ) receptor modulation in mediating the antidepressant action of ropinirole hydrochloride, a D2/D3 dopamine receptor agonist
2. Drug vis‐à‐vis consumer: a retrospection
3. Critical review of ropinirole and pramipexole - putative dopamine D3-receptor selective agonists - for the treatment of RLS
4. Randomized trials of dopamine agonists in restless legs syndrome: A systematic review, quality assessment, and meta-analysis
5. Pharmacological Management of Psychosis in Elderly Patients with Parkinsonism
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