Separation of amyloid β fragment peptides with racemised and isomerised aspartic acid residues using an original chiral resolution labeling reagent-Reference-Cited by-同舟云学术

Separation of amyloid β fragment peptides with racemised and isomerised aspartic acid residues using an original chiral resolution labeling reagent

Published:2023 Issue:6 Volume:148 Page:1209-1213
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Ozaki Makoto¹,Shimotsuma Motoshi¹,Kuranaga Takefumi²,Kakeya Hideaki²^ORCID,Hirose Tsunehisa¹^ORCID

Affiliation:

1. Research and Development Department, Purification Section, Nacalai Tesque, Inc., Ishibashi Kaide-cho, Muko-shi, Kyoto 617-0004, Japan

2. Department of System Chemotherapy and Molecular Sciences, Division of Medicinal Frontier Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Kyoto 606-8501, Japan

Abstract

We developed a system to separate and identify racemised and isomerised aspartic acid residues in amyloid β by labeling with an original chiral resolution labeling reagent, d-FDLDA.

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/AN/D2AN01885C

Reference20 articles.

1. The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

2. Amyloid-Beta: A Crucial Factor in Alzheimer's Disease

3. Alzheimer's disease: synaptic dysfunction and Aβ

4. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

5. Amino- and carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain

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