Supramolecular polyplexes from Janus peptide nucleic acids (bm-PNA-G5): self-assembled bm-PNA G-quadruplex and its tetraduplex with DNA-Reference-Cited by-同舟云学术

Supramolecular polyplexes from Janus peptide nucleic acids (bm-PNA-G5): self-assembled bm-PNA G-quadruplex and its tetraduplex with DNA

Published:2024 Issue:33 Volume:22 Page:6810-6821
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Todkari Iranna Annappa¹²^ORCID,Chaudhary Preeti¹,Kulkarni Mahesh J.³^ORCID,Ganesh Krishna N.¹²⁴^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr Homi Bhabha Road, Pune 411008, India

2. Department of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Karkambadi Road, Tirupati 517507, India

3. Division of Biochemistry, CSIR-National Chemical Laboratory, Pashan Road, Pune 411008, India

4. New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bengaluru 560064, India

Abstract

Janus like bimodal Peptide Nucleic acids (bm-PNA) can form diverse secondary structures with complementary DNA, ranging from double duplex to triplex of duplex, triple duplex and tetraduplex of tetraplex.

Funder

Department of Science and Technology, Ministry of Science and Technology

Indian Institute of Science Education and Research Pune

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00968A

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4. PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules

5. Potential of Peptide Nucleic Acids in Future Therapeutic Applications