Dual colorimetric and fluorogenic probes for visualizing tyrosine phosphatase activity
Author:
Affiliation:
1. Department of Medicinal Chemistry
2. University of Utah College of Pharmacy
3. Salt Lake City
4. USA
5. Department of Oncological Sciences
6. University of Utah School of Medicine
7. Department of Pathology
Abstract
Two resorufin-based substrates were developed, providing sensitive fluorogenic readouts for PTP activityin vitroand in living cells.
Funder
Teva Pharmaceutical Industries
Division of Chemistry
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2017/CC/C6CC09204G
Reference37 articles.
1. Protein Tyrosine Phosphatases in the Human Genome
2. Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction
3. Protein tyrosine phosphatase variants in human hereditary disorders and disease susceptibilities
4. Protein tyrosine phosphatases and the immune response
5. Inside the human cancer tyrosine phosphatome
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