Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases-Reference-Cited by-同舟云学术

Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases

Published:2012 Issue:7 Volume:3 Page:829
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Beckers Thomas,Mahboobi Siavosh,Sellmer Andreas,Winkler Matthias,Eichhorn Emerich,Pongratz Herwig,Maier Thomas,Ciossek Thomas,Baer Thomas,Kelter Gerhard,Fiebig Heinz-Herbert,Schmidt Mathias

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2012/MD/C2MD00317A

Reference25 articles.

1. Acetylation of EGF receptor contributes to tumor cell resistance to histone deacetylase inhibitors

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4. Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor

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