Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

Author:

Poreba Marcin12345,Rut Wioletta12345,Vizovisek Matej6789,Groborz Katarzyna12345,Kasperkiewicz Paulina12345,Finlay Darren101112ORCID,Vuori Kristiina101112,Turk Dusan6789,Turk Boris6789,Salvesen Guy S.101112,Drag Marcin12345ORCID

Affiliation:

1. Department of Bioorganic Chemistry

2. Faculty of Chemistry

3. Wroclaw University of Technology

4. 50-370 Wroclaw

5. Poland

6. Department of Biochemistry and Molecular and Structural Biology

7. Jožef Stefan Institute

8. SI-1000 Ljubljana

9. Slovenia

10. Sanford Burnham Prebys Medical Discovery Institute

11. La Jolla

12. USA

Abstract

Highly-selective fluorogenic substrate and activity-based probe for monitoring cathepsin L activity in the breast cancer cell line MDA-MB-231.

Funder

National Institutes of Health

Fundacja na rzecz Nauki Polskiej

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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