The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement-Reference-Cited by-同舟云学术

The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement

Published:2019 Issue:28 Volume:17 Page:6790-6798
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Houston Sevan D.¹²³⁴,Fahrenhorst-Jones Tyler¹²³⁴^ORCID,Xing Hui¹²³⁴,Chalmers Benjamin A.¹²³⁴^ORCID,Sykes Melissa L.⁵⁶⁷³⁴^ORCID,Stok Jeanette E.¹²³⁴,Farfan Soto Clementina¹²³⁴,Burns Jed M.¹²³⁴^ORCID,Bernhardt Paul V.¹²³⁴^ORCID,De Voss James J.¹²³⁴,Boyle Glen M.⁸⁹³⁴^ORCID,Smith Maree T.¹⁰¹¹¹²³⁴^ORCID,Tsanaktsidis John¹³¹⁴¹⁵⁴,Savage G. Paul¹³¹⁴¹⁵⁴,Avery Vicky M.⁵⁶⁷³⁴^ORCID,Williams Craig M.¹²³⁴^ORCID

Affiliation:

1. School of Chemistry and Molecular Biosciences

2. University of Queensland (UQ)

3. Brisbane

4. Australia

5. Discovery Biology

6. Griffith Institute for Drug Discovery

7. Griffith University

8. QIMR Berghofer Medical Research Institute

9. PO Royal Brisbane Hospital

10. School of Biomedical Sciences

11. Faculty of Medicine

12. UQ

13. CSIRO Manufacturing

14. Ian Wark Laboratory

15. Melbourne

Abstract

Trials and tribulations of the cubane paradigm in biomolecule discovery highlight synthetic limitations, culminating in a continuing guide for practitioners, which includes cyclooctatetraene.

Funder

University of Queensland

Griffith University

QIMR Berghofer Medical Research Institute

Department of Agriculture and Water Resources, Australian Government

Commonwealth Scientific and Industrial Research Organisation

Australian Research Council

National Health and Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry