Design, synthesis, crystal structure, in vitro cytotoxicity evaluation, density functional theory calculations and docking studies of 2-(benzamido) benzohydrazide derivatives as potent AChE and BChE inhibitors

Author:

Kausar Naghmana1ORCID,Murtaza Shahzad1,Arshad Muhammad Nadeem23,Zaib Saleem Rahman Shah4ORCID,Asiri Abdullah M.23ORCID,Kausar Samia15,Altaf Ataf Ali6ORCID,Tatheer Adina1,Elnaggar Ashraf Y.7ORCID,El-Bahy Salah M.8

Affiliation:

1. Department of Chemistry, University of Gujrat, Gujrat, 50700, Pakistan

2. Chemistry Department, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi Arabia

3. Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi Arabia

4. Lahore University of Management Sciences (LUMS), Lahore, Pakistan

5. Catalysis Research Center, Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85747 Garching, Germany

6. Department of Chemistry, University of Okara, Okara 56300, Pakistan

7. Department of Food Nutrition Science, College of Science, Taif University, P. O. Box 11099, Taif 21944, Saudi Arabia

8. Department of Chemistry, Turabah University College, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

Abstract

2-(Benzamido) benzohydrazide derivatives: synthesis from methyl anthranilate and application as potent anti-Alzheimer's agents.

Funder

Taif University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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