Testing Aβ toxicity on primary CNS cultures using drug-screening microfluidic chips-Reference-Cited by-同舟云学术

Testing Aβ toxicity on primary CNS cultures using drug-screening microfluidic chips

Published:2014 Issue:15 Volume:14 Page:2860-2866
ISSN:1473-0197
Container-title:Lab Chip
language:en
Short-container-title:Lab Chip

Author:

Ruiz A.¹²³⁴⁵,Joshi P.¹²³,Mastrangelo R.¹²³⁶⁷,Francolini M.¹²³⁴⁵,Verderio C.⁸³⁹¹⁰,Matteoli M.¹²³⁹¹⁰

Affiliation:

1. Department of Medical Biotechnologies and Translational Medicine

2. University of Milan

3. 20129 Milan, Italy

4. Fondazione Filarete

5. 20139 Milan, Italy

6. Department of Life Science

7. University of Trieste

8. CNR-Institute of Neurosciences

9. Humanitas Clinical and Research Center

10. 20089 Rozzano, Italy

Abstract

Neuronal viability tests performed in primary cultures and co-cultures of the central nervous system grown on microfluidic drug screening chips show a neuroprotective action of FTY720 in cultures degenerated by oligomeric beta amyloid.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2014/LC/C4LC00174E

Reference31 articles.

1. Role of Axonal Transport in Neurodegenerative Diseases

2. The Dark Side of Glia

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5. Amyloid Precursor Protein Processing and Alzheimer's Disease

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