Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner-Reference-Cited by-同舟云学术

Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner

Published:2018 Issue:9 Volume:16 Page:1465-1479
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Fedorka Sara R.¹²³⁴⁵,So Kevin¹²³⁴⁵,Al-Hamashi Ayad A.¹²³⁴⁵,Gad Ibtissam⁶⁷³⁴⁵,Shah Ronit⁶⁷³⁴⁵,Kholodovych Veronika⁶⁷³⁴⁵,Alqahtani Hanan D.⁶⁷³⁴⁵,Taylor William R.⁶⁷³⁴⁵,Tillekeratne L. M. Viranga¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal and Biological Chemistry

2. College of Pharmacy and Pharmaceutical Sciences

3. The University of Toledo

4. Toledo

5. USA

6. Department of Biological Sciences

7. College of Natural Sciences and Mathematics

Abstract

In the course of generating a library of open-chain epothilones, we discovered a new class of small molecule anticancer agents that has no effect on tubulin but instead kills selected cancer cell lines by harnessing reactive oxygen species in an iron-dependent manner.

Funder

Elsa U. Pardee Foundation

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB03086J

Reference17 articles.

1. G. Hoefle , N.Bedorf , K.Gerth and H.Reichenbach , Epothilone derivatives , 1993

2. Chemical Biology of Epothilones