Solvent-free amide bond formation using a variety of methoxysilanes as coupling agent-Reference-Cited by-同舟云学术

Solvent-free amide bond formation using a variety of methoxysilanes as coupling agent

Published:2022 Issue:18 Volume:20 Page:3717-3720
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lainer Thomas¹,Czerny Frank²,Haas Michael¹^ORCID

Affiliation:

1. Institute of Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria

2. Department of Chemistry, Metalorganics and Inorganic Materials, Technische Universität Berlin, Strasse des 17. Juni 135, Sekr. C2, 10623 Berlin, Germany

Abstract

A new solvent-free procedure for the formation of amide bonds without exclusion of air and moisture is described. As coupling agent tetramethoxysilane 1, hexamethoxydisilane 2 and dodecamethoxyneopentasilane 3 were used.

Funder

Austrian Science Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00589A

Reference34 articles.

1. The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

2. Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited

3. Expanding the medicinal chemistry synthetic toolbox