Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs-Reference-Cited by-同舟云学术

Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs

Published:2019 Issue:42 Volume:10 Page:9663-9672
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Li Hongyu¹²³⁴⁵^ORCID,Valkenier Hennie⁶³⁷⁵^ORCID,Thorne Abigail G.⁶³⁷⁵,Dias Christopher M.⁶³⁷⁵^ORCID,Cooper James A.⁶³⁷⁵^ORCID,Kieffer Marion⁶³⁷⁵^ORCID,Busschaert Nathalie⁸⁹¹⁰⁵^ORCID,Gale Philip A.⁸⁹¹⁰⁵^ORCID,Sheppard David N.¹²³⁴⁵^ORCID,Davis Anthony P.⁶³⁷⁵^ORCID

Affiliation:

1. School of Physiology

2. Pharmacology and Neuroscience

3. University of Bristol

4. Bristol BS8 1TD

5. UK

6. School of Chemistry

7. Bristol BS8 1TS

8. Chemistry

9. University of Southampton

10. Southampton SO17 1BJ

Abstract

Synthetic anion transporters are active in cystic fibrosis cells, and are additive to clinically-approved drugs, suggesting new combination therapies for this lethal genetic condition.

Funder

Engineering and Physical Sciences Research Council

Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC04242C

Reference55 articles.

1. Development of synthetic membrane transporters for anions

2. Anion transport and supramolecular medicinal chemistry