Post-SELEX modifications with locked nucleic acids (LNA) of a SEA-specific DNA aptamer assisted by <i>in silico</i> modelling-Reference-Cited by-同舟云学术

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Post-SELEX modifications with locked nucleic acids (LNA) of a SEA-specific DNA aptamer assisted by in silico modelling

Published:2024 Issue:8 Volume:9 Page:847-855
ISSN:2058-9689
Container-title:Molecular Systems Design & Engineering
language:en
Short-container-title:Mol. Syst. Des. Eng.

Author:

Oliveira Ricardo¹²³^ORCID,Pinho Eva¹²³,Azevedo Nuno Filipe²³,Almeida Carina¹²³⁴

Affiliation:

1. INIAV – National Institute for Agrarian and Veterinarian Research, Rua dos Lagidos, 4485-655 Vairão, Vila do Conde, Portugal

2. LEPABE – Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal

3. AliCE – Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal

4. Centre of Biological Engineering (CEB), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal

Abstract

Post-SELEX modifications assisted by in silico modelling are powerful tools to improve the performance of aptamers, by providing a rational approach for the selection of modified-versions.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/ME/D4ME00043A

Reference37 articles.

1. Aptamers and the RNA World, Past and Present

2. SELEX—A (r)evolutionary method to generate high-affinity nucleic acid ligands

3. Aptamers as therapeutics

4. Locked Nucleic Acid and Aptamers

5. Aptamers Overview: Selection, Features and Applications

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