Rosmarinic acid ameliorates renal interstitial fibrosis by inhibiting the phosphorylated-AKT mediated epithelial–mesenchymal transition <i>in vitro</i> and <i>in vivo</i>-Reference-Cited by-同舟云学术

Rosmarinic acid ameliorates renal interstitial fibrosis by inhibiting the phosphorylated-AKT mediated epithelial–mesenchymal transition in vitro and in vivo

Published:2022 Issue:8 Volume:13 Page:4641-4652
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Hsieh Yi-Hsien¹²,Tsai Jen-Pi³⁴,Ting Yi-Hsuan¹,Hung Tung-Wei⁵⁶,Chao Wen-Wan⁷^ORCID

Affiliation:

1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

2. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan

3. School of Medicine, Tzu Chi University, Hualien, Taiwan

4. Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan

5. Division of Nephrology, Department of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan

6. School of Medicine, Chung Shan Medical University, Taichung, Taiwan

7. Department of Nutrition and Health Sciences, Kainan University, Taoyuan, Taiwan

Abstract

Indoxyl sulfate (IS), a uremic toxin, causes chronic kidney disease (CKD) progression via renal fibrosis.

Funder

Ministry of Science and Technology, Taiwan

Dalin Tzu Chi Hospital

Buddhist Tzu Chi Medical Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO00204C

Reference40 articles.

1. High Prevalence and Low Awareness of CKD in Taiwan: A Study on the Relationship Between Serum Creatinine and Awareness From a Nationally Representative Survey

2. Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis

3. Indoxyl Sulfate, a Uremic Endotheliotoxin

4. Indoxyl Sulfate, a Tubular Toxin, Contributes to the Development of Chronic Kidney Disease

5. Epithelial-Mesenchymal Transitions in Development and Disease

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