Combined cytotoxic effect of UV-irradiation and TiO2microbeads in normal urothelial cells, low-grade and high-grade urothelial cancer cells

Author:

Imani Roghayeh12345,Veranič Peter67345,Iglič Aleš89345,Kreft Mateja Erdani67345,Pazoki Meysam1011121314,Hudoklin Samo67345

Affiliation:

1. Laboratory of Clinical Biophysics

2. Faculty of Health Sciences

3. University of Ljubljana

4. Ljubljana

5. Slovenia

6. Institute of Cell Biology

7. Faculty of Medicine

8. Laboratory of Biophysics

9. Faculty of Electrical Engineering

10. Department of Chemistry

11. Ångström Laboratory

12. Physical Chemistry

13. University of Uppsala

14. SE 75120 Uppsala

Abstract

Paper shows that internalization of the TiO2microbeads followed by the UV-irradiation is an efficient approach for killing cancer urothelial cells. Additionally, differentiation dependent differences in the sensitivity of the cells to the UV-irradiation are shown, and a model of photocatalytic treatment of thein vivobladder cancer is presented.

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry

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