Gold(i)-catalyzed stereoselective cyclization of 1,3-enyne aldehydes by a 1,3-acyloxy migration/Nazarov cyclization/aldol addition cascade
Author:
Affiliation:
1. Laboratorium für Organische Chemie, HCI H335
2. Eidgenössische Technische Hochschule Zürich
3. 8093 Zürich
4. Switzerland
Abstract
Optically active 1,3-enyne aldehydes undergo stereoselective, Au-catalyzed conversion to bicyclo[3.3.0]octenones (up to 97% ee, good d.r.) via a domino sequence involving 1,3-acyloxy migration, Nazarov cyclization and an unprecedented aldol addition.
Funder
Eidgenössische Technische Hochschule Zürich
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC02828E
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