Insight into the SEA amide thioester equilibrium. Application to the synthesis of thioesters at neutral pH
Author:
Affiliation:
1. Univ. Lille
2. CNRS
3. Institut Pasteur de Lille
4. UMR 8161 – M3T – Mechanisms of Tumorigenesis and Target Therapies
5. F-59000 Lille
6. Université Sidi Mohamed Ben Abdellah
7. Morocco
Abstract
Peptide alkylthioesters can be prepared at neutral pH by bis(2-sulfanylethyl)amide-thiol exchange.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01079B
Reference40 articles.
1. Synthesis of Proteins by Native Chemical Ligation
2. Chemoselective Amide Ligations by Decarboxylative Condensations ofN-Alkylhydroxylamines and α-Ketoacids
3. Bis(2-sulfanylethyl)amino Native Peptide Ligation
4. Total chemical synthesis of proteins
5. Sequential native peptide ligation strategies for total chemical protein synthesis
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