A modified xanthine oxidase cell model for screening of antihyperuricemic functional compounds-Reference-Cited by-同舟云学术

A modified xanthine oxidase cell model for screening of antihyperuricemic functional compounds

Published:2022 Issue:20 Volume:13 Page:10546-10557
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Hou Chuanli¹,Sha Wangqian¹,Li Yujuan¹,Yao Maojin²,Ren Jiaoyan¹³^ORCID

Affiliation:

1. School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China

2. The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Disease and China State Key Laboratory of Respiratory Disease, Guangzhou 510182, China

3. China-Singapore International Joint Research Institute, Huangpu District, Guangzhou, 510663, China

Abstract

A cell model for hyperuricemia was established, in vitro, employing cultured HK-2 cells. It was validated for rapid screening of urate-lowering compounds. It may be used as an in vitro model to screen antihyperuricemic compounds that mimic in vivo cell growth patterns.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO00297C

Reference21 articles.

1. High serum uric acid levels increase the risk of metabolic syndrome in elderly women: The PRO.V.A study

2. Purine-Rich Foods, Dairy and Protein Intake, and the Risk of Gout in Men