A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation

Author:

Stephens Elisa N.1ORCID,Zhang Xiao-Nan1ORCID,Lam Albert T.1,Li Jiawei1,Pei Hua2,Louie Stan G.23,Wang Clay C. C.14ORCID,Zhang Yong1345ORCID

Affiliation:

1. Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA

2. Titus Family Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA

3. Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA

4. Department of Chemistry, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA 90089, USA

5. Research Center for Liver Diseases, University of Southern California, Los Angeles, CA 90089, USA

Abstract

An NAD+ featuring an adenosyl 4′-azido functions as a general substrate for poly-ADP-ribose polymerases.

Funder

University of Southern California

National Cancer Institute

National Institute of Biomedical Imaging and Bioengineering

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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