A non-enzymatic, isothermal amplification sensor for quantifying the relative abundance of Akkermansia muciniphila

Author:

Liu Bing12,Shi Chen1,Wang Fan1,Xu Fangling1,Chao Jie2ORCID,Zhu Jiapeng1,Yang Dongliang2ORCID,Ouyang Xiangyuan3ORCID

Affiliation:

1. School of Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China

2. Key Laboratory for Organic Electronics and Information Displays and Jiangsu, Key Laboratory for Biosensors, Institute of Advanced Materials, National Synergetic Innovation Center for Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing, Jiangsu 210023, China

3. Xi'an Key Laboratory of Functional Supramolecular Structure and Materials, Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an, Shaanxi 710127, China

Abstract

We have developed a non-enzymatic, isothermal amplification assay (NIA sensor) based on a catalytic hairpin assembly (CHA) reaction for quantifying the relative abundance of Akkermansia muciniphila.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shaanxi Province

Publisher

Royal Society of Chemistry (RSC)

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