In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells-Reference-Cited by-同舟云学术

In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells

Published:2020-10-27 Issue:12 Volume:12 Page:1931-1940
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:

Author:

Balsa Lucia M¹,Quispe Patricia¹,Baran Enrique J¹,Lavecchia Martin J¹,León Ignacio E¹^ORCID

Affiliation:

1. Centro de Química Inorgánica (CEQUINOR, CONICET-UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bv 120 1465, 1900 La Plata, Argentina

Abstract

Abstract The study of novel mechanisms of action of vanadium compounds is critical to elucidating the role and importance of these kinds of compounds as antitumor and antimetastatic agents. This work deals with in silico and in vitro studies of one clioquinol oxidovanadium(iv) complex [VO(clioquinol)2], VO(CQ)2, and its regulation of FAK. In particular, we focus on elucidating the relationship of the FAK inhibition, MMP activity and antimetastatic effects of the complex in human bone cancer cells.

Funder

Universidad Nacional de La Plata

Consejo Nacional de Investigaciones Científicas y Técnicas

Agencia Nacional de Promoción Científica y Tecnológica

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

https://academic.oup.com/metallomics/article-pdf/12/12/1931/41703043/d0mt00176g.pdf

Reference60 articles.

1. Vanadium compounds in medicine