Development of a method for the quantitative metabolite profiling of pharmaceutical drugs using HPLC-ICP-MS following pre-column derivatization of their amino and hydroxyl groups using 4-aminopyridine as a model compound-Reference-Cited by-同舟云学术

Development of a method for the quantitative metabolite profiling of pharmaceutical drugs using HPLC-ICP-MS following pre-column derivatization of their amino and hydroxyl groups using 4-aminopyridine as a model compound

Published:2019 Issue:4 Volume:34 Page:708-715
ISSN:0267-9477
Container-title:Journal of Analytical Atomic Spectrometry
language:en
Short-container-title:J. Anal. At. Spectrom.

Author:

Li Sanwang¹²³⁴⁵^ORCID,Cuyckens Filip⁶⁷⁸⁵^ORCID,Lynen Frederic¹⁹¹⁰⁴⁵^ORCID,Vanhaecke Frank¹²³⁴⁵^ORCID

Affiliation:

1. Ghent University

2. Department of Chemistry

3. Atomic and Mass Spectrometry (A&MS) Research Unit

4. 9000 Ghent

5. Belgium

6. Janssen R&D

7. Drug Metabolism & Pharmacokinetics

8. 2340 Beerse

9. Department of Organic and Macromolecular Chemistry

10. Separation Science Group

Abstract

Presence of amino and/or hydroxyl groups allows for derivatization of APIs and their metabolites with 4-iodobenzoylchloride, thus enabling HPLC-ICP-MS metabolite profiling.

Funder

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Spectroscopy,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/JA/C8JA00386F

Reference32 articles.

1. Hyphenation of reverse-phase HPLC and ICP-MS for metabolite profiling—application to a novel antituberculosis compound as a case study

2. Speciation analysis of bromine-containing drug metabolites in feces samples from a human in vivo study by means of HPLC/ICP-MS combined with on-line isotope dilution

3. HPLC/ICP-MS in Combination with “Reverse” Online Isotope Dilution in Drug Metabolism Studies

4. Application of HPLC-ICP-MS to speciation of cisplatin and its degradation products in water containing different chloride concentrations and in human urine

5. Determination of levothyroxine and its degradation products in pharmaceutical tablets by HPLC-UV-ICP-MS

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