Development of hypoxia-activated PROTAC exerting a more potent effect in tumor hypoxia than in normoxia-Reference-Cited by-同舟云学术

Development of hypoxia-activated PROTAC exerting a more potent effect in tumor hypoxia than in normoxia

Published:2021 Issue:95 Volume:57 Page:12852-12855
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Cheng Weiyan¹²^ORCID,Li Shasha¹²,Wen Xueqian¹²,Han Siyuan¹²,Wang Suhua¹²,Wei Han¹²,Song Zhizhen¹²,Wang Yueqin¹²,Tian Xin¹²,Zhang Xiaojian¹²

Affiliation:

1. Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China

2. Henan Key Laboratory of Precision Clinical Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Abstract

In this manuscript, for the first time, we report the development of a kind of hypoxia-activated PROTAC that shows a more potent degradation activity in the tumor hypoxia environment than in normoxia.

Funder

National Natural Science Foundation of China

Science and Technology Department of Henan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC05715D

Reference40 articles.

1. Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia

2. Molecular landmarks of tumor hypoxia across cancer types

3. Hypoxia-targeted drug delivery

4. Hypoxia: A Double-Edged Sword in Cancer Therapy

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