Exploring PAZ/3′-overhang interaction to improve siRNA specificity. A combined experimental and modeling study-Reference-Cited by-同舟云学术

Exploring PAZ/3′-overhang interaction to improve siRNA specificity. A combined experimental and modeling study

Published:2018 Issue:8 Volume:9 Page:2074-2086
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Alagia Adele¹²³⁴²^ORCID,Jorge Andreia F.⁵⁶⁷⁸⁹^ORCID,Aviñó Anna¹²³⁴²^ORCID,Cova Tânia F. G. G.⁵⁶⁷⁸⁹^ORCID,Crehuet Ramon¹²³^ORCID,Grijalvo Santiago¹²³⁴²^ORCID,Pais Alberto A. C. C.⁵⁶⁷⁸⁹^ORCID,Eritja Ramon¹²³⁴²^ORCID

Affiliation:

1. Institute for Advanced Chemistry of Catalonia (IQAC-CSIC)

2. E-08034 Barcelona

3. Spain

4. Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)

5. CQC

6. Department of Chemistry

7. University of Coimbra

8. 3004-535 Coimbra

9. Portugal

Abstract

A direct connection between the PAZ/3′-overhang binding affinity and the siRNA potency and specificity is defined through complementary experimental and computational results.

Funder

Fundação para a Ciência e a Tecnologia

Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina

Departament d’Innovació, Universitats i Empresa, Generalitat de Catalunya

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC00010G

Reference69 articles.