Highly stereoselective gram scale synthesis of all the four diastereoisomers of Boc-protected 4-methylproline carboxylates-Reference-Cited by-同舟云学术

Highly stereoselective gram scale synthesis of all the four diastereoisomers of Boc-protected 4-methylproline carboxylates

Published:2019 Issue:55 Volume:9 Page:32017-32020
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sun Kehuan¹²³⁴⁵,Tao Cheng⁶²³⁴⁵,Long Bohua⁵⁷⁴⁸⁹^ORCID,Zeng Xiaobin¹⁰¹¹¹²¹³¹⁴^ORCID,Wu Zhengzhi⁵⁷⁴⁸⁹,Zhang Ronghua¹²³⁴

Affiliation:

1. College of Traditional Chinese Medicine

2. Jinan University

3. Guangzhou 510632

4. China

5. The First Affiliated Hospital of Shenzhen University

6. Integrated Chinese and Western Medicine Postdoctoral Research Station

7. Shenzhen 518035

8. Shenzhen Institute of Geriatric Medicine

9. Shenzhen

10. Central Center Lab of Longhua Branch

11. Department of Infectious Disease

12. Shenzhen People's Hospital

13. 2nd Clinical Medical College of Jinan University

14. Shenzhen 518120

Abstract

A general and practical synthetic process for all the four diastereoisomers of Boc-protected 4-methylproline carboxylates has been developed with essentially complete stereoselectivity on gram scale.

Funder

National Natural Science Foundation of China

Sanming Project of Medicine in Shenzhen

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA06827A

Reference25 articles.

1. Nazumazoles A–C, Cyclic Pentapeptides Dimerized through a Disulfide Bond from the Marine Sponge Theonella swinhoei

2. Monamycin synthetic studies. Pt 1. An enantiospecific total synthesis of (3S,5S)-5-hydroxypiperazic acid from D-mannitol

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