Drug-likeness of linear pentamidine analogues and their impact on the hERG K+channel – correlation with structural features-Reference-Cited by-同舟云学术

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Drug-likeness of linear pentamidine analogues and their impact on the hERG K+channel – correlation with structural features

Published:2019 Issue:66 Volume:9 Page:38355-38371
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Żołek Teresa¹²³⁴⁵^ORCID,Qile Muge⁶⁷⁸⁹¹⁰,Kaźmierczak Paweł¹²³⁴⁵,Bloothooft Meye⁶⁷⁸⁹¹⁰,van der Heyden Marcel A. G.⁶⁷⁸⁹¹⁰,Maciejewska Dorota¹²³⁴⁵^ORCID

Affiliation:

1. Department of Organic Chemistry

2. Faculty of Pharmacy

3. Medical University of Warsaw

4. 02-097 Warsaw

5. Poland

6. Department of Medical Physiology

7. Division Heart & Lungs

8. University Medical Center Utrecht

9. Utrecht

10. The Netherlands

Abstract

The pentamidines with S atoms or sulfanilide groups in the linker have favorable drug-likeness parameters and low toxicity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA08404E

Reference70 articles.

1. A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs

2. Screening lead compounds for QT interval prolongation

3. hERG potassium channels and cardiac arrhythmia

4. The hERG potassium channel and hERG screening for drug-induced torsades de pointes

5. Repolarization Reserve

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