Screening of efficient salicylaldoxime reactivators for DFP and paraoxon-inhibited acetylcholinesterase-Reference-Cited by-同舟云学术

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Screening of efficient salicylaldoxime reactivators for DFP and paraoxon-inhibited acetylcholinesterase

Published:2024 Issue:4 Volume:15 Page:1225-1235
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Wei Zhao¹^ORCID,Zhang Dongxu¹,Liu Xueying¹,Nie Huifang¹,Ouyang Qin²^ORCID,Zhang Xinlei¹,Zheng Zhibing³

Affiliation:

1. Department of Medicinal Chemistry and Pharmaceutical analysis, School of Pharmacy, Air Force Medical University, Xi'an 300071, China

2. Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, Chongqing, 400038, China

3. Department of Medicinal Chemistry, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China

Abstract

Dual-site binding mode of lead compounds with AChE and construction of novel salicylaldoxime reactivators using a fragment-based drug design strategy.

Funder

National Natural Science Foundation of China

Key Research and Development Projects of Shaanxi Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00628J

Reference56 articles.

1. Nerve Agents: What They Are, How They Work, How to Counter Them

2. No promising antidote 25 years after the Tokyo subway sarin attack: A review

3. Novichok agents: a historical, current, and toxicological perspective

4. Management of acute organophosphorus pesticide poisoning

5. Pharmacological treatment of organophosphorus insecticide poisoning: the old and the (possible) new

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