Amphotericin B-loaded mannose modified poly(d,l-lactide-co-glycolide) polymeric nanoparticles for the treatment of visceral leishmaniasis: in vitro and in vivo approaches

Author:

Ghosh Santanu12345ORCID,Das Suman12345,De Asit Kumar12345,Kar Nabanita12345,Bera Tanmoy12345

Affiliation:

1. Laboratory of Nanomedicine

2. Division of Pharmaceutical Biotechnology

3. Department of Pharmaceutical Technology

4. Jadavpur University

5. Kolkata-700 032

Abstract

Amphotericin B-loaded mannose modified PLGA nanoparticles are more efficacious in the treatment of visceral leishmaniasis in bothin vitroandin vivomodels than unmodified nanoformulations.

Funder

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference40 articles.

1. World Health Organization (2014), Global Health Observatory Data – Leishmaniasis, available at: http://www.who.int/gho/neglected_diseases/leishmaniasis/en/GlobalHealthObservatory, accessed on April 21, 2015

2. Travel and migration associated infectious diseases morbidity in Europe, 2008

3. The immunology of Leishmania/HIV co-infection

4. Leishmaniasis Worldwide and Global Estimates of Its Incidence

5. In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

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