Discovery of human TyrRS inhibitors by structure-based virtual screening, structural optimization, and bioassays-Reference-Cited by-同舟云学术

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Discovery of human TyrRS inhibitors by structure-based virtual screening, structural optimization, and bioassays

Published:2019 Issue:16 Volume:9 Page:9323-9330
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Huang Shenzhen¹²³⁴⁵^ORCID,Wang Xiang⁶⁷⁸⁹⁵,Lin Guifeng¹²³⁴⁵,Cheng Jie¹²³⁴⁵,Chen Xiuli¹²³⁴⁵,Sun Weining¹⁰¹¹¹²⁴⁵,Xiang Rong⁶⁷⁸⁹⁵,Yu Yamei¹²³⁴⁵,Li Linli¹⁰¹¹¹²⁴⁵,Yang Shengyong¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center

2. West China Hospital

3. Sichuan University/Collaborative Innovation Center of Biotherapy

4. Chengdu

5. China

6. Department of Clinical Medicine

7. School of Medicine

8. Nankai University

9. Tianjin 300071

10. Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education

11. West China School of Pharmacy

12. Sichuan University

Abstract

A small molecule with potent activity diverts human Tyrosyl-tRNA synthetase (TyrRS) to the nucleus for protection against DNA damage.

Funder

National Natural Science Foundation of China

Sichuan University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA00458K

Reference37 articles.

1. Resveratrol improves health and survival of mice on a high-calorie diet

2. Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

3. Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

4. Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model

5. Small-Molecule Allosteric Activators of Sirtuins

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1. Computational methods and tools for sustainable and green approaches in drug discovery;Green Approaches in Medicinal Chemistry for Sustainable Drug Design;2024

2. Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation;GeroScience;2020-11-27

3. Discovery of Potent Small-Molecule SIRT6 Activators: Structure–Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity;Journal of Medicinal Chemistry;2020-08-12

4. Computational methods and tools for sustainable and green approaches in drug discovery;Green Approaches in Medicinal Chemistry for Sustainable Drug Design;2020

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