Chromatin hierarchical branching visualized at the nanoscale by electron microscopy
Author:
Affiliation:
1. Bindley Bioscience Center
2. Department of Agricultural and Biological Engineering
3. Purdue University
4. West Lafayette
5. USA
6. Markey Center for Structural Biology
7. Department of Biological Science
Abstract
Interphase chromatin in mammalian cells is spatially organized in a hierarchical branching manner allowing easy genomic transition from lower order nucleosomal arrays to higher order heterochromatin.
Funder
W. M. Keck Foundation
Indiana Clinical and Translational Sciences Institute
Publisher
Royal Society of Chemistry (RSC)
Subject
General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering
Link
http://pubs.rsc.org/en/content/articlepdf/2021/NA/D0NA00359J
Reference49 articles.
1. Crystal structure of the nucleosome core particle at 2.8 Å resolution
2. Spheroid Chromatin Units (ν Bodies)
3. How the Genome Folds: The Biophysics of Four-Dimensional Chromatin Organization
4. Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo
5. Chromosome territories, nuclear architecture and gene regulation in mammalian cells
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