Synthesis of A-ring quinolones, nine-membered oxolactams and spiroindoles by oxidative transformations of 2,3-indolotriterpenoids

Author:

Khusnutdinova Elmira F.123ORCID,Kazakova Oxana B.123ORCID,Lobov Alexander N.123ORCID,Kukovinets Olga S.123,Suponitsky Kyrill Yu.4563ORCID,Meyers Craig B.789,Prichard Mark N.10119

Affiliation:

1. Ufa Institute of Chemistry – Subdivision of the Ufa Federal Research Centre of Russian Academy of Sciences

2. Ufa 450054

3. Russian Federation

4. A.N. Nesmeyanov Institute of Organoelement Compounds

5. Russian Academy of Sciences

6. Moscow 119334

7. Penn State College of Medicine

8. Hershey

9. USA

10. University of Alabama at Birmingham

11. Birmingham

Abstract

An access to new antiviral A-ring quinolones, oxolactams and spiroindoles by oxidation of 2,3-indolo-triterpenoids with ozone and dimethyldioxirane is reported.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference58 articles.

1. Allobetulin and Its Derivatives: Synthesis and Biological Activity

2. Betulinic acid and its derivatives: a patent review (2008 – 2013)

3. Advances in Chemistry and Pharmacology of Triterpenoid Synthetic Dimers

4. G. W. Gribble , Indole Ring Synthesis: From Natural Products to Drug Discovery , Book Wiley , 2016 , 704 pages, ISBN: 978-0-470-51218-0

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