Enhancement of the properties of a drug by mono-deuteriation: reduction of acid-catalysed formation of a gut-motilide enol ether from 8-deuterio-erythromycin B-Reference-Cited by-同舟云学术

Enhancement of the properties of a drug by mono-deuteriation: reduction of acid-catalysed formation of a gut-motilide enol ether from 8-deuterio-erythromycin B

Published:2016 Issue:26 Volume:14 Page:6289-6296
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bhadra Pranab K.¹²³⁴,Hassanzadeh Abdolreza¹²³⁴,Arsic Biljana¹²³⁴,Allison David G.¹²³⁴,Morris Gareth A.⁵²³⁴,Barber Jill¹²³⁴

Affiliation:

1. Manchester Pharmacy School

2. University of Manchester

3. Manchester

4. UK

5. School of Chemistry

Abstract

An efficient synthesis of 8-d-erythromycin B was achieved. A deuterium isotope effect suppresses formation of the corresponding enol ether, which may result in reduced gut-motilide effects.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00785F

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