Ganoderma lucidum methyl ganoderate E extends lifespan and modulates aging-related indicators in Caenorhabditis elegans

Author:

Okoro Nkwachukwu Oziamara123,Odiba Arome Solomon14,Han Junjie4ORCID,Osadebe Patience Ogoamaka3,Omeje Edwin Ogechukwu3,Liao Guiyan1,Liu Yichen12,Jin Cheng4,Fang Wenxia12ORCID,Liu Hongwei4ORCID,Wang Bin1ORCID

Affiliation:

1. Institute of Biological Sciences and Technology, Guangxi Academy of Sciences, Nanning 530007, China

2. College of Life Science and Technology, Guangxi University, Nanning 530004, China

3. Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka 410001, Nigeria

4. State Key Lab of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

Abstract

Ganoderma lucidum methyl ganoderate E (MGE) improves healthspan and extends lifespan through the insulin/IGF-1 pathway, modulating neuroactive signaling and ubiquitin-mediated proteolysis.

Funder

National Institutes of Health

Agricultural Science and Technology Innovation Program

Guangxi Key Research and Development Program

Natural Science Foundation of Shandong Province

Guangxi Academy of Sciences

Specific Research Project of Guangxi for Research Bases and Talents

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Reference52 articles.

1. Pathways of cellular proteostasis in aging and disease

2. The Hallmarks of Aging

3. UN DESA, Ageing and disability|United Nations Enable, United Nations Department of Economic and Social Affairs. https://www.un.org/development/desa/disabilities/disability-and-ageing.html

4. Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in Caenorhabditis elegans

5. Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster

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