Predicting the conformational variability of oncogenic GTP-bound G12D mutated KRas-4B proteins at zwitterionic model cell membranes-Reference-Cited by-同舟云学术

Predicting the conformational variability of oncogenic GTP-bound G12D mutated KRas-4B proteins at zwitterionic model cell membranes

Published:2022 Issue:8 Volume:14 Page:3148-3158
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Lu Huixia¹^ORCID,Martí Jordi²^ORCID

Affiliation:

1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China

2. Department of Physics, Polytechnical University of Catalonia-Barcelona Tech, B5-209 Northern Campus, Jordi Girona 1-3, 08034 Barcelona, Catalonia, Spain

Abstract

Representative stable states for active methylated KRas-4B proteins at the cell membrane's interface and structural evolution of druggable pockets Switch I and Switch II along the Minimum Free-Energy Path.

Funder

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D1NR07622A

Reference87 articles.

1. U1 snRNP regulates cancer cell migration and invasion in vitro

2. Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas

3. RAS oncogenes: weaving a tumorigenic web