Sirt6-mediated Nrf2/HO-1 activation alleviates angiotensin II-induced DNA DSBs and apoptosis in podocytes-Reference-Cited by-同舟云学术

Sirt6-mediated Nrf2/HO-1 activation alleviates angiotensin II-induced DNA DSBs and apoptosis in podocytes

Published:2021 Issue:17 Volume:12 Page:7867-7882
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Fan Yanqin¹²^ORCID,Cheng Jing³,Yang Qian¹²,Feng Jun¹²,Hu Jijia¹²,Ren Zhilong¹²,Yang Hongxia¹²,Yang Dingping¹²,Ding Guohua¹²

Affiliation:

1. Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China

2. Nephrology and Urology Research Institute of Wuhan University, Wuhan, Hubei, China

3. Division of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China

Abstract

Sirt6 upregulation inhibited Ang II-induced ROS generation and DNA DSBs in podocytes, and it shows the cytoprotective effects in podocytes via the Nrf2/HO-1 pathway. Sirt6 may be a new therapeutic target for the treatment of CKD.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D0FO03467C

Reference55 articles.

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4. Contribution of TGF-Beta-Mediated NLRP3-HMGB1 Activation to Tubulointerstitial Fibrosis in Rat With Angiotensin II-Induced Chronic Kidney Disease

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