Thioanisole ester based logic gate cascade to control ROS-triggered micellar degradation-Reference-Cited by-同舟云学术

Thioanisole ester based logic gate cascade to control ROS-triggered micellar degradation

Published:2022 Issue:16 Volume:13 Page:2383-2390
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Piergentili Irene¹^ORCID,Bouwmans Pepijn R.¹,Reinalda Luuk¹,Lewis Reece W.¹^ORCID,Klemm Benjamin¹^ORCID,Liu Huanhuan²,de Kruijff Robin M.²^ORCID,Denkova Antonia G.²,Eelkema Rienk¹^ORCID

Affiliation:

1. Delft University of Technology, Department of Chemical Engineering, Van der Maasweg 9, 2629 HZ Delft, The Netherlands

2. Delft University of Technology, Department of Radiation Science and Technology, Mekelweg 15, 2629 JB Delft, The Netherlands

Abstract

Thioanisole ester polymer side chains hydrolyze exclusively upon thioether oxidation, showing logic gate response. ROS-induced ester hydrolysis on the hydrophobic domain leads to nanocarrier disassembly with potential for targeted drug release.

Funder

National Natural Science Foundation of China

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/PY/D2PY00207H

Reference63 articles.

1. Amphiphilic block copolymers for drug delivery

2. Recent advances in stimuli-responsive polymer systems for remotely controlled drug release