Vibrational and chiroptical analysis of blood plasma for hepatocellular carcinoma diagnostics

Author:

Vrtělka Ondřej1ORCID,Králová Kateřina1ORCID,Fousková Markéta1ORCID,Habartová Lucie1ORCID,Hříbek Petr23ORCID,Urbánek Petr2,Setnička Vladimír1ORCID

Affiliation:

1. Department of Analytical Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic

2. Military University Hospital Prague, Department of Medicine 1st Faculty of Medicine Charles University and Military University Hospital Prague, U Vojenské nemocnice 1200, 169 02 Prague 6, Czech Republic

3. Department of Internal Medicine, University of Defense, Faculty of Military Health Sciences in Hradec Kralove, Třebešská 1575, 500 01 Hradec Kralove, Czech Republic

Abstract

Using a combination of vibrational and chiroptical spectroscopy together with principal component analysis and a random forest algorithm, we have successfully distinguished patients with hepatocellular carcinoma from patients with cirrhosis.

Funder

Ministerstvo Zdravotnictví Ceské Republiky

Vysoká Škola Chemicko-technologická v Praze

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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