Tauroursodeoxycholic acid (TUDCA) counters osteoarthritis by regulating intracellular cholesterol levels and membrane fluidity of degenerated chondrocytes-Reference-Cited by-同舟云学术

Tauroursodeoxycholic acid (TUDCA) counters osteoarthritis by regulating intracellular cholesterol levels and membrane fluidity of degenerated chondrocytes

Published:2019 Issue:8 Volume:7 Page:3178-3189
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Arai Yoshie¹²³⁴,Choi Bogyu⁵⁶⁷⁴,Kim Byoung Ju¹²³⁴,Rim Wongyu⁵⁶⁷⁴,Park Sunghyun¹²³⁴,Park Hyoeun¹²³⁴,Ahn Jinsung¹²³⁴,Lee Soo-Hong¹²³⁴^ORCID

Affiliation:

1. Department of Medical Biotechnology

2. Dongguk University-Seoul

3. 04620 Seoul

4. South Korea

5. Department of Biomedical Science

6. CHA University

7. Pangyo-ro

Abstract

TUDCA promote the chondrogenic properties of osteoarthritic chondrocytes at submicellar concentrations by reducing the intracellular cholesterol and increasing membrane fluidity.

Funder

National Research Foundation of Korea

Dongguk University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/BM/C9BM00426B

Reference49 articles.

1. Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes

2. The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis