Glycolipids from the gut symbiont <i>Bacteroides fragilis</i> are agonists for natural killer T cells and induce their regulatory differentiation-Reference-Cited by-同舟云学术

Glycolipids from the gut symbiont Bacteroides fragilis are agonists for natural killer T cells and induce their regulatory differentiation

Published:2023 Issue:29 Volume:14 Page:7887-7896
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Cameron Garth¹^ORCID,Nguyen Tram²³,Ciula Marcin¹,Williams Spencer J.²³^ORCID,Godfrey Dale I.¹

Affiliation:

1. Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia

2. School of Chemistry, University of Melbourne, Parkville, VIC 3010, Australia

3. Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia

Abstract

Total synthesis of a glycolipid antigen and structural analogues from the human gut commensal Bacteroides fragilis enables demonstration of its antigenic properties and immunoregulatory activity.

Funder

National Health and Medical Research Council

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC02124F

Reference41 articles.

1. Bacteroides : the Good, the Bad, and the Nitty-Gritty

2. A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease