Amphipathic design dictates self-assembly, cytotoxicity and cell uptake of arginine-rich surfactant-like peptides

Author:

Mello Lucas R.123,Aguiar Rodrigo B.123,Yamada Renata Y.123,Moraes Jane Z.123,Hamley Ian W.4567ORCID,Alves Wendel A.89103ORCID,Reza Mehedi11121314,Ruokolainen Janne11121314,Silva Emerson R.123ORCID

Affiliation:

1. Departamento de Biofísica

2. Universidade Federal de São Paulo

3. Brazil

4. Department of Chemistry

5. University of Reading

6. Reading

7. UK

8. Centro de Ciências Naturais e Humanas

9. Universidade Federal do ABC

10. Santo André

11. Nanomicroscopy Center

12. Aalto University

13. FIN-02150 Espoo

14. Finland

Abstract

Amphiphilicity is the most critical parameter in the self-assembly of surfactant-like peptides, regulating the way by which hydrophobic attraction holds peptides together.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Engineering and Physical Sciences Research Council

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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