On-the-spot quenching for effective implementation of cooling crystallization in a continuous-flow microfluidic device-Reference-Cited by-同舟云学术

On-the-spot quenching for effective implementation of cooling crystallization in a continuous-flow microfluidic device

Published:2022 Issue:5 Volume:7 Page:1179-1190
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Coliaie Paria¹,Kelkar Manish S.²,Korde Akshay²,Langston Marianne³,Liu Chengxiang⁴,Nazemifard Neda⁵,Patience Daniel⁴,Skliar Dimitri⁶,Nere Nandkishor K.¹²,Singh Meenesh R.¹^ORCID

Affiliation:

1. Department of Chemical Engineering, University of Illinois at Chicago, 929 W. Taylor St., Chicago, IL 60607, USA

2. Center of Excellence for Isolation & Separation Technologies (CoExIST), Process R&D, AbbVie Inc., North Chicago, IL 60064, USA

3. Pharmaceutics Research – Analytical Development, Takeda Pharmaceuticals International Co., Cambridge, MA 02139, UK

4. Pharmaceutical Development, Biogen, Cambridge, MA 02142, UK

5. Chemical Process Development, Takeda Pharmaceuticals International Co., Cambridge, MA 02139, UK

6. Chemical Process Development, Product Development, Bristol Myers Squibb Co., New Brunswick, NJ 08901, USA

Abstract

Illustrated is a microfludic cooling crystallization device that can effectively screen polymorphs, growth rates, and morphology of crystalline materials.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RE/D2RE00029F

Reference20 articles.

1. A.Mersmann , Crystallization technology handbook , CRC press , 2001

2. Advances and New Directions in Crystallization Control

3. A Review of Heating and Temperature Control in Microfluidic Systems: Techniques and Applications