Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone-Reference-Cited by-同舟云学术

Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone

Published:2016 Issue:6 Volume:7 Page:3785-3790
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kalhor-Monfared S.¹²³⁴,Jafari M. R.¹²³⁴,Patterson J. T.⁵⁶⁷,Kitov P. I.¹²³⁴,Dwyer J. J.⁵⁶⁷,Nuss J. M.⁵⁶⁷,Derda R.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Alberta

3. Edmonton

4. Canada

5. Ferring Research Institute

6. San Diego

7. USA

Abstract

In this manuscript, we describe modification of Cys-residues in peptides and proteins in aqueous solvents via aromatic nucleophilic substitution (S_NAr) with perfluoroarenes (fAr).

Funder

Alberta Glycomics Centre

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC03856A

Reference42 articles.

1. Lead discovery and optimization strategies for peptide macrocycles

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3. Peptide therapeutics: Targeting the undruggable space

4. Contemporary strategies for peptide macrocyclization

5. Inhibition of α-helix-mediated protein–protein interactions using designed molecules

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