Graphene oxide size and oxidation degree govern its supramolecular interactions with siRNA-Reference-Cited by-同舟云学术

Graphene oxide size and oxidation degree govern its supramolecular interactions with siRNA

Published:2018 Issue:13 Volume:10 Page:5965-5974
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Reina Giacomo¹²³⁴⁵^ORCID,Chau Ngoc Do Quyen¹²³⁴⁵,Nishina Yuta⁶⁷⁸⁹¹⁰^ORCID,Bianco Alberto¹²³⁴⁵^ORCID

Affiliation:

1. University of Strasbourg

2. CNRS

3. Immunology, Immunopathology and Therapeutic Chemistry

4. UPR 3572

5. 67000 Strasbourg

6. Precursory Research for Embryonic Science and Technology

7. Japan Science and Technology Agency

8. Kawaguchi

9. Japan

10. Research Core for Interdisciplinary Sciences

Abstract

We systematically studied the interactions between graphene oxide (GO) and siRNA. The siRNA secondary structure is damaged by the interaction with GO sheets. Functionalization of GO with polyethyleneimine is able to protect siRNA from structural modifications.

Funder

Horizon 2020 Framework Programme

Agence Nationale de la Recherche

Centre National de la Recherche Scientifique

Centre International de Recherche aux Frontières de la Chimie

Japan Science and Technology Corporation

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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