Sphingomyelinase-responsive nanomicelles for targeting atherosclerosis

Author:

Muñoz-Hernando María12,Nogales Paula2ORCID,Fernández-Barahona Irene1,Ruiz-Cabello Jesús3456,Bentzon Jacob F.27,Herranz Fernando16ORCID

Affiliation:

1. Grupo de Nanomedicina e Imagen Molecular, Instituto de Química Médica (IQM/CSIC), Juan de la Cierva 3, 28006 Madrid, Spain

2. Centro Nacional de Investigaciones Cardiovasculares, CNIC, Melchor Fernández-Almagro 3, 28029 Madrid, Spain

3. CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo de Miramon 182, 20014, Donostia San Sebastián, Spain

4. Ikerbasque, Basque Foundation for Science, Plaza Euskadi 5, 4800 Bilbao, Spain

5. NMR and Imaging in Biomedicine Group, Department of Chemistry in Pharmaceutical Sciences, Pharmacy School, University Complutense Madrid, 28040 Madrid, Spain

6. CIBER Enfermedades Respiratorias (CIBERES), Melchor Fernández-Almagro 3, 28029 Madrid, Spain

7. Department of Clinical Medicine, Aarhus University, Denmark

Abstract

Sphingomyelinase enzymatic activity destabilises iron oxide nanomicelles and promotes its accumulation in atherosclerosis in vivo.

Funder

Ministerio de Economía, Industria y Competitividad, Gobierno de España

Ministerio de Ciencia e Innovación

Comunidad de Madrid

“la Caixa” Foundation

Instituto de Salud Carlos III

Centro Nacional de Investigaciones Cardiovasculares

Publisher

Royal Society of Chemistry (RSC)

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