Encapsulation of 5-fluorouracil in cholesteryl-modified cyclodextrin: thermal, spectral, and computational assessment of drug inclusion efficiency-Reference-Cited by-同舟云学术

Encapsulation of 5-fluorouracil in cholesteryl-modified cyclodextrin: thermal, spectral, and computational assessment of drug inclusion efficiency

Published:2024 Issue:29 Volume:12 Page:7063-7075
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Misiak Paweł¹^ORCID,Maliszewski Bartosz¹²^ORCID,Pawłowska Zuzanna¹,Ignaczak Anna³^ORCID,Wilczewska Agnieszka Z.¹^ORCID

Affiliation:

1. Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Poland

2. Doctoral School of Exact and Natural Sciences, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Poland

3. Theoretical and Structural Chemistry Group, Department of Physical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163/165, 90-236, Lodz, Poland

Abstract

This study explores the encapsulation of 5-fluorouracil (5-FU) within cholesteryl-modified β-cyclodextrin (CD21chol), aiming to elucidate the drug inclusion efficiency through a detailed analysis using both experimental and computational methods.

Funder

Narodowe Centrum Nauki

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D4TB00496E

Reference35 articles.

1. 5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future

2. Synergistic effect of folate-conjugated polymers and 5-fluorouracil in the treatment of colon cancer

3. 5-Fluorouracil: mechanisms of action and clinical strategies

4. Novel 5-Fluorouracil Carbonate-Loaded Liposome: Preparation, In Vitro, and In Vivo Evaluation as an Antitumor Agent

5. Formulation and evaluation of a smart drug delivery system of 5-fluorouracil for pH-sensitive chemotherapy