Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator-Reference-Cited by-同舟云学术

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Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator

Published:2015 Issue:2 Volume:6 Page:1237-1246
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Proctor Elizabeth A.¹²³⁴⁵,Kota Pradeep⁵²³⁴⁶,Aleksandrov Andrei A.⁶²³⁴⁷,He Lihua⁶²³⁴⁷,Riordan John R.⁶²³⁴⁷,Dokholyan Nikolay V.¹²³⁴⁵

Affiliation:

1. Curriculum in Bioinformatics and Computational Biology

2. University of North Carolina

3. Chapel Hill

4. USA

5. Program in Molecular and Cellular Biophysics

6. Department of Biochemistry and Biophysics

7. Cystic Fibrosis Treatment and Research Center

Abstract

A novel approach identifying networks of residues involved intrans-protein dynamic coupling is applied to rescue mutant CFTR.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C4SC01320D

Reference50 articles.

1. Allosteric Mechanisms of Signal Transduction

2. Allosteric regulation and catalysis emerge via a common route

3. Is allostery an intrinsic property of all dynamic proteins?

4. A Unified View of “How Allostery Works”

5. Dynamically driven protein allostery

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