Practical chemoselective aromatic substitution: the synthesis of <i>N</i>-(4-halo-2-nitrophenyl)benzenesulfonamide through the efficient nitration and halogenation of <i>N</i>-phenylbenzenesulfonamide-Reference-Cited by-同舟云学术

Practical chemoselective aromatic substitution: the synthesis of N-(4-halo-2-nitrophenyl)benzenesulfonamide through the efficient nitration and halogenation of N-phenylbenzenesulfonamide

Published:2022 Issue:27 Volume:20 Page:5444-5451
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yu Xiao¹,Zhu Wenjing¹,Liu Hongyan¹,Liu Yi¹,Li Hongshuang¹^ORCID,Han Junfen¹,Duan Guiyun¹,Bai Zhushuang¹^ORCID,Zhang Pengfei²^ORCID,Xia Chengcai¹^ORCID

Affiliation:

1. Institute of Pharmacology, Pharmacy College, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016, China

2. College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, China

Abstract

A novel route involving the metal-promoted tandem nitration and halogenation of N-phenylbenzenesulfonamide to synthesize N-(4-halo-2-nitrophenyl)benzenesulfonamide derivatives has been developed.

Funder

Science and Technology Development Plan of Shandong Province

Shandong First Medical University

Zhejiang Provincial Ten Thousand Plan for Young Top Talents

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01028C

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